Pilot Study of the Safety and Feasibility of Ultrasound-Guided Fine Needle Aspiration following Hepatitis B Vaccination of Healthy Adults

We are doing this study to find out if it is possible to do a procedure called a “fine needle aspiration” or “FNA” after someone is vaccinated. In this study, we want to do FNAs of lymph nodes in the armpit after vaccinating with a licensed hepatitis B vaccine, to see if we can detect special immune cells against the hepatitis B virus. Eventually, we want to use this procedure in a study of a new vaccine against HIV that is being developed. However, before we do that, we need to figure out if this procedure works. That is why we want to use a very well-known and safe vaccine – the hepatitis B vaccine called “ENGERIX-B” – that has been given to millions of people around the world, including the United States, to learn if the FNA procedure will be useful.

Primary Sponsor:

Prinicipal Investigator:
Dr. David Diemert/Microbiology, Immunology and Tropical Medicine

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