Cancer & Blood Disorders Amgen 20070782 A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long-term Safety and Efficacy of Darbepoetin Alfa Administered at 500 µg Once-Every-3-Weeks in Anemic Subjects With Advanced Stage Non-small Cell Lung Cancer Receiving Multi-cycle Chemotherapy.
Cancer & Blood Disorders Breast Cancer - ECOG 5103 A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide followed by Paclitaxel with Bevacizumab or Placebo in Patients with Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer.
Cancer & Blood Disorders IBCSG 25-02 (TEXT) A Phase III Trial Evaluating the Role of Exemestane Plus GnRH Analogue as Adjuvant Therapy for Premenopausal Women with Endocrine Responsive Breast Cancer.  
Cancer & Blood Disorders LYM. MANTLE C - 1) Cephalon C1803/2039/NL/US-CA An Open-Label Study of Bendamustine Hydrochloride in Combination with Rituximab in the treatment of Patients With Relapsed/Refractory Mantle Cell Lymphoma.
Cancer & Blood Disorders LYMPHOMA - Pharmatech PI-08904 Bendamustine Combined with Rituximab for Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
Cancer & Blood Disorders MULTIPLE MYELOMA - Cephalon C18083/1063/MM/US An Open-Label Study of Bendamustine Combined with Bortezomib for Patients with Relapsed/Refractory Multiple Myeloma.
Cancer & Blood Disorders MYELO DYSPLASTIC SYNDROME - Amgen 197 An Open Label Extension Study Evaluating the Safety in Long Term Dosing of AMG 531 in Thrombocytopenic Subjects with Myelodysplastic Syndrome (MDS).
Cancer & Blood Disorders MYELO DYSPLASTIC SYNDROME - Amgen 198 A Randomized, Double-Blind, Placebo Controlled Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Thrombocytopenia in Subjects with Low or Intermediate-1 Risk Myelodyplastic syndrome (MDS).
Cancer & Blood Disorders Pilot project to determine the role of Circulating Tumor Cells (CTC) in patients with prostate specific antigen (PSA) only recurrence and its association with PSA doubling time Pilot project to determine the role of Circulating Tumor Cells (CTC) in patients with prostate specific antigen (PSA) only recurrence and its association with PSA doubling time.
Cancer & Blood Disorders PROSTATE CANCER - CALGB 90203 Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients with High-Risk, Clinically Localized Prostate Cancer.
Cancer & Blood Disorders PROSTATE CANCER - Medivation Protocol No. CRPC2 A Multinational Phase 3, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Oral MDV3100 in Patients with Progressive Castration-Resistant Prostate Cancer Previously Treated with Docetaxel-Based Chemotherapy.
Cardiology ASTRONAUT A multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the 6 months efficacy and safety of aliskiren therapy on top of standard therapy, on morbidity and mortality when initiated early after hospitalization for acute decompensated heart failure.
Cardiology CABANA Pulmonary Vein Ablation compared to Medical Therapy in Management of A-Fib CABANA is designed to test the hypothesis that the treatment strategy of left atrial catheter ablation for the purpose of the elimination of atrial fibrillation (AF) is superior to current state-of-the-art therapy (rate control or anti arrhythmic drugs) in patients with untreated or incompletely treated AF warranting therapy.
Cardiology Dal-Heart Study For patients with recent acute coronary syndrome. Oral CETP (cholesteryl ester transfer protein) “dalcetrapib = DAL”or placebo added to current therapy (Raising HDL through CETP inhibition).
Cardiology RESPECT The purpose of this study is to investigate whether percutaneous Patent Foramen Ovale (PFO) closure, using the AMPLATZER PFO Occluder, is superior to current standard of care medical treatment in the prevention of recurrent embolic stroke.
Cardiology RIVAL This study compares a trans-radial approach during cardiac catheterization for patients with acute coronary syndromes to a trans-femoral approach. The hypothesis is that radial access site PCI will be associated with significantly less major bleeding and access site complications compared with a femoral approach, without increasing the risk of ischemic events. The overall benefit-risk profile will favor a trans-radial approach.
Dermatology Novel Drug Delivery of Sodium Thiosulfate for Calcinosis Associated with Adult and Juvenile Dermatomyositis The purpose of this study is to investigate the ability of fractional carbon dioxide laser and topical sodium thiosulfate solution to treat superficial calcinosis (calcium deposits in the skin) in individuals with juvenile and adult dermatomyositis. Improvement in patient functionality and/or quality of life will also be assessed. Patients may be enrolled at the MFA Departments of Dermatology and Rheumatology.
Dermatology Psoriasis: Prevalence of Non-Alcoholic Fatty Liver Disease Among Patients With Psoriasis The purpose of this study is to determine the prevalence of non alcoholic fatty liver disease (NAFLD) in subjects with psoriasis compared to the non-psoriatic population by performing a limited right upper quadrant abdominal ultrasonography. Patients seen in the MFA Psoriasis Clinic may be eligible to participate in this study.
Dermatology Psoriasis: Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoria The purpose of this study is to measure serum lipid levels in subjects with and without psoriasis by using a detailed cholesterol test that gives a more accurate determination of LDL (bad cholesterol) and a better assessment of lipid-contribution to cardiovascular risk compared to standard lipid profiles. Markers of inflammation that contribute to cardiovascular disease will also be measured. Patients seen in the MFA Psoriasis Clinic may be eligible to participate in this study.
Endocrinology Type 1 Diabetes: ANDROMEDA 1001: Efficacy and Safety Study of DiaPep277 in Newly Diagnosed Type 1 Diabetes Adults (DIA-AID2) This study will look at the effectiveness and safety of DiaPep277 for preservation of insulin secretion in adults with newly diagnosed type 1 diabetes. DiaPep277 is a peptide that alters the body's immune system attack on insulin-producing beta-cells that occurs during the development of type 1 diabetes. Adults (ages 20-45 years) with newly diagnosed (< 6 months) type 1 diabetes will be treated with 10 injections of DiaPep277 or placebo approximately every three months over a 24-month treatment and follow-up period.
Infectious Diseases FLU003: An International Observational Study to Characterize Adults Who Are Hospitalized With Complications of Influenza A - Pandemic H1N1 (H1N1v) The purpose of this observational study is to describe the characteristics and outcomes over a 60-day follow-up period of participants with influenza A –  pandemic H1N1 (H1N1v) who are hospitalized with severe and/or complicated influenza A. This information will be used to guide policymakers and to advise on the management of patients who are hospitalized with the flu. Over 1,000 individuals will be enrolled worldwide.
Infectious Diseases Influenze: FLU002: An International Observational Study to Characterize Adults with Influenza A - Pandemic H1N1 (H1N1v) The purpose of this study is to better understand the course of illness for those who have H1N1v and the characteristics of people who do not do well. Investigators will also try to learn more about how different treatments and prior vaccination for the flu affect the course of the illness. Eligible participants with suspected influenza must be seeking treatment prior to enrollment in the study. Approximately 5,000 individuals with the flu will be enrolled in several countries around the world.
Infectious Diseases POEM: Prospective Observational Epidemiologic Study of Maraviroc's Safety The study will assess if the use of maraviroc (Selzentry) along with an optimized background regimen of antiretroviral drugs in usual clinical practice is as safe as using only an optimized regimen of antiretroviral drugs in treatment-experienced HIV-1 infected patients. Patients seen in the MFA Infectious Diseases Clinic may be eligible to participate in this study.
Kidney Disease & Hypertension SPRINT (Systolic Blood Pressure Intervention Trial) The Systolic Blood Pressure Intervention Trial (SPRINT) is a National Institute of Health funded 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk, memory decline, or worsening kidney disease.  Participants diagnosed with hypertension and other CVD events will be closely monitored through monthly blood pressure readings, physical examinations, blood and urine tests, and questionnaires.
Pain & Non-Operative Spine Service Discogenic Lumbar Back Pain- TransDiscal System A prospective, randomized, multi-center, open-label clinical trial comparing disc biacuplasty with medical management for discogenic lumbar back pain.
Pain & Non-Operative Spine Service mild® Decompression vs. Epidural Steroid Injection mild® decompression alternative to open surgery epidural steroid injection comparative outcomes study (MiDAS ECO) in patients diagnosed with moderate to severe lumbar spinal stenosis exhibiting neurogenic claudication.
Pain & Non-Operative Spine Service Radiofrequency Ablation of Lumbar Medial Branch with the LumbarCool System This is an investigator initiated study that aims to develop a technical description of lumbar medial branch ablation using the LumbarCool system.  The procedure uses cooled radiofrequency (cooled-RF) technology in treating patients with diagnosed lumbar facet joint pain.
Radiology ABUS (somo•InSIGHT) A higher sensitivity to breast cancer detection can be achieved in women with dense breast tissue by performing and reviewing results of Automated Breast Ultrasound (ABUS) and Digital X-Ray Mammography (XRM) together as part of routine screening compared to performing and reviewing results of XRM alone.
Radiology Accuracy of Philips MammoDiagnost DR versus Screen Film in the Detection of Breast Cancer Eligible patient undergo both screen film and the FFDM mammography. The images then undergo a reader study to evaluate the performance of the FFDM mammogram. This study is only recruiting women who are scheduled for a breast biopsy.
Rheumatology Environmental Exposure and Disease Flare in Adult and Juvenile Dermatomyositis and Polymyositis The study examines environmental exposures in adult and juvenile dermatomyositis and polymyositis and whether the environmental exposures contribute to a disease flare.
Rheumatology Speech and Voice assessments in Adult and Children with Myositis Disorders The study examines the incidence of speech and voice abnormalities in children and adults with idiopathic inflammatory myopathies (myositis disorders), and assesses strength of muscles involved in speech, respiration and articulation, and functionality of respiratory, phonatory, articulatory and resonance systems in perception and production of speech in patients with myositis disorders.
Vascular Surgery JETSTREAM NAVITUS™ SYSTEM ENDOVASCULAR THERAPY POST-MARKET REGISTRY The JET Registry is a multi-center, open label, multiple group assignment, non-randomized registry of up to 500 patients with symptomatic peripheral vascular disease undergoing percutaneous intervention using with the MEDRAD Jetstream Navitus™ System.  The Jetstream System is a rotating, aspirating, expandable catheter for active removal of atherosclerotic disease and thrombus in peripheral vasculature.  The purpose of this post-market registry is to observe the treatment effects of the Navitus™ system in long, occluded, diffuse, thrombotic or calcified lesions in peripheral arterial disease of the common femoral, superficial femoral or popliteal arteries and to assess and quantify vessel patency 1 year post atherectomy treatment.
Vascular Surgery The Pivotal Study of the Safety and Effectiveness of Autologous Bone Marrow Aspirate Concentrate (BMAC) for the Treatment of Critical Limb Ischemia Due to Peripheral Arterial Disease This study is a randomized, controlled, double blinded, multi-center clinical research investigation of a medical device which produces BMAC, concentrated live cells from the patient’s own body.  The purpose of this study is to evaluate the safety and effectiveness of BMAC in treating patients diagnosed with critical limb ischemia due to peripheral arterial occlusive disease who are not likely to benefit from any other recognized treatment.  It is hypothesized that BMAC prepared from the patient’s own bone marrow and injected into the muscle around areas of ischemia in the lower leg & foot has the potential to improve perfusion in that ischemic limb.